Introduction to Systems Biology

This course provides an introduction to the biological and theoretical concepts of Systems Biology. It covers the biological basics, benefits and limitations of mathematical modelling of biochemical networks, fundamentals of mathematical modelling of biochemical networks and an introduction to model parameterization, simulation and analysis.

The following topics will be covered in the run of the course:

• What is Systems Biology?
• Biological basics in a nutshell
• Biochemical fundamentals
• Benefits and limitations of mathematical modelling in Biology
• Mathematical models in Systems Biology
• Dynamic modelling of biochemical networks, reaction kinetics
• Model parameterization, model analysis and simulation

Prof. Dr.-Ing. Rolf Findeisen
Institute for Automation Engineering

Room G07-202
0391/6718708

Dr. rer. nat. Daniela Dieterich
Leibniz Institute for Neurobiology
Emmy Noether Research Group Neuralomics
Brenneckestr. 6
39118 Magdeburg
Germany
0391/6263-132 or -210

Emily Hammes
Room G07-209
0391/6718776

Monday, October 4, 2010 to Friday, Octover 8, 2010

Monday 4.10

09:00-09:15	Welcome, Overview and Organization (D. Dieterich, R. Findeisen)
09:15-09:30	Systems Biology?
09:30-11:15	Diversity of Life Organisms (D. Dieterich)
11:30-13:00	Cells (D. Dieterich)
14:00-15:30	Exercise I
15:45-16:30	Drosophila, A Systems Biology Model Organism (U. Thomas, Leibniz Institute for Neurobiology)

Tuesday 5.10

09:00-10:30	Chemistry of Life (D. Dieterich)
10:45-12:45	Biochemistry of Cells (D. Dieterich)
13:30-15:00	Mathematical Modelling in Systems Biology (R. Findeisen)
15:30-16:30	Exercise II

Wednesday 6.10

09:00-10:30	Modeling Biochemical Reaction Networks I (R. Findeisen)
10:45-12:15	Modeling Biochemical Reaction Networks II (R. Findeisen)
13:00-14:30	Exercise III
14:45-15:30	Phototaxis: A Systems Biology Perspective (S. Streif, OvGU-Magdeburg)

Thursday 6.10

09:00-09:45	Cellular Signal Transduction (Fred Schaper, OvGU Magdeburg)
10:00-11:30	Modeling Biochemical Reaction Networks III (R. Findeisen)
13:00-14:30	Analysis in Systems Biology I (R. Findeisen)
14:45-16:15	Exercise IV

Friday 7.10

09:00-10:30	Analysis in Systems Biology II (R. Findeisen)
10:45-12:15	Analysis in Systems Biology III, Exercise V (R. Findeisen)
12:15-13:00	Wrapup, Questions, Summary, Discussion (D. Dieterich, R. Findeisen)

The lecture consists of

• lecture classes
• in class exercises
• supplemetary talks by people working in the field of systems biology in Magdeburg
• additional reading material
• a mini-project, needs to be prepared before the oral exam

There will be an oral examination. For an appointment, please talk to the lecturers during the class.

PF STK; B6
IMPRS-Students

All necessary material will be handed out during the lecture. After the block seminar the course material can be downloaded from the web-page.